Can I take antidepressants if I'm pregnant?

If you find yourself struggling with depression during pregnancy, you’re not alone. During pregnancy, 14–23 percent of women will experience symptoms of depression. Pregnancy can also trigger emotions that make depression more difficult to cope with.

Detecting depression is important

While changes in sleep, appetite, and libido (sex drive) are commonplace during pregnancy, they can also be signals for depression. The risks of untreated depression can be serious and can affect the health of mothers and babies. As the Mayo Clinic notes, depression can cause moms to miss prenatal care, not eat foods that are good for them and their babies, and not have the energy to take care of themselves. Some moms even turn to smoking or drinking alcohol. All of these increase the risks for premature birth, low birth weight, fetal growth restriction, postpartum depression, and other problems.

You can get treatment even when pregnant 

You may have been told that you shouldn’t take antidepressants when you’re pregnant. But treatment is available—even during pregnancy. 

The decision to use antidepressants during pregnancy is based on weighing the risks and benefits. In a recent extensive study, some antidepressants were found to slightly increase the risk of birth defects. But others were found to bring no added risk. Even for those medications that increased the risk, the overall risk was found to be small.

Meanwhile, the value of reducing the dangers that depression poses for you and your baby is enormous.

These antidepressants can be used

These antidepressants are generally considered an option during pregnancy, according to the Mayo Clinic:

  • Certain selective serotonin reuptake inhibitors (SSRIs). These include citalopram (Celexa) and sertraline (Zoloft).
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs). These include duloxetine (Cymbalta) and venlafaxine (Effexor XR).
  • Bupropion (Wellbutrin). This isn't generally considered a first-line treatment for depression during pregnancy but might be an option for women who haven’t responded to other medications.
  • Tricyclic antidepressants. This class of medications includes amitriptyline and nortriptyline (Pamelor). These aren’t generally considered a first-line or second-line treatment but might be an option for those who haven't responded to other medications.

These antidepressants should be avoided

The Mayo Clinic notes that the SSRI paroxetine (Paxil) is generally discouraged during pregnancy. And some research suggests that Paxil may be associated with a small increase in fetal heart defects.

In addition, monoamine oxidase inhibitors (MAOIs) might limit fetal growth and so are generally discouraged during pregnancy. These include phenelzine (Nardil) and tranylcypromine (Parnate).

Talk to your doctor if you have a history of depression

If you’re planning a pregnancy and have a history of depression or postpartum depression, talk with your health care provider about which treatment or medication is best. If you have mild depression, it may be that you can find relief through counseling, with or without medication—it’s the first line of treatment recommended by medical authorities for pregnant and postpartum women. But if you have more severe depression, you may be able to start or continue with one of the safer medications.

All such decisions should be made with your doctor and after considering your current health and personal history. Not all antidepressants work the same for all women, and side effects can vary.

And if you’re currently taking an antidepressant but want to explore discontinuing it during pregnancy, talk with your health care provider first. The New York State Office of Mental Health notes that women who stop taking their antidepressant medication during pregnancy may get depression again and so put themselves and their infants at risk. Your health care provider can guide you on the best strategy for weaning from the medication, if recommended, and discuss the safety of alternative treatments and the need for followup.

Last updated March 2, 2021

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